A renewed interest in Accelerator Mass Spectrometry (AMS) from nuclear physics laboratories is emerging in connection with Radioactive Ion Beams (RIBs). At the Holifield Radioactive Ion Beam Facility (HRIBF) at Oak Ridge National Laboratory (ORNL) we are exploring the AMS capabilities of the 25-MV tandem accelerator. Behind this effort is the realization that two fields of research -AMS and RIBs -complement each other in techniques. Development of effective and efficient beam purification techniques is of common interest to both AMS and the RIB program. Two main characteristics of the 25-MV tandem provide unique opportunities for performing the highest sensitivity measurements of AMS; namely (i) the highest operating voltage in the world, and (ii) a folded geometry which involves a 180°magnet in the terminal. For the RIB program, we have used AMS techniques to improve the sensitivity of detection of some radioactive species in the measurement of unknown masses of n-rich nuclei. For AMS, we have concentrated in exploring two important isotopes, 14 C and 36 Cl, for applications that require the highest sensitivity. We have successfully measured 36 Cl/Cl ratios as low as a few times 10 À16 in seawater samples demonstrating that our setup has the highest sensitivity for this isotope and proving that 36 Cl can be measured at the levels required for a tracer in oceanography.