Push-out testing and histological evaluation of glass reinforced hydroxyapatite composites implanted in the tibia of rabbits
✍ Scribed by Lopes, M. A. ;Santos, J. D. ;Monteiro, F. J. ;Ohtsuki, C. ;Osaka, A. ;Kaneko, S. ;Inoue, H.
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 432 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
In vitro and in vivo bioactivity studies were performed to assess the biocompatibility of CaO-P 2 O 5 glassreinforced hydroxyapatite (GR-HA) composites. The ability to form an apatite layer by soaking in simulated body fluid (SBF) was examined and surfaces were characterized using FTIR reflection and thin-film X-ray diffraction analyses. Qualitative histology, histomorphometric measurements, and push-out testing were performed in a rabbit model for characterizing bone/implant bonding. Under the in vitro conditions using SBF, an apatite layer could not be formed on GR-HA composites within 8 weeks. Results of push-out testing showed bonding between the composites and bone, ranging from 130-145 N after 2 weeks of implantation. After the longest implantation period, 16 weeks, the GR-HA composite prepared with the higher content of CaO-P 2 O 5 glass showed the highest bonding force, 606 ± 45 N, compared to 459 ± 30 N for sintered HA. Development of immature bone and modifications in the turnover of a more mature bone on the surface of GR-HA composites were similar to those on sintered HA.