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Purpurins and benzochlorins as sensitizers for photodynamic therapy

✍ Scribed by Greta M. Garbo

Book ID
103994719
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
992 KB
Volume
34
Category
Article
ISSN
1011-1344

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✦ Synopsis

Purpurins and benzochlorins are hydrophobic second generation photosensitizers, which have sizable absorption in the 650-780 nm range and exhibit photodynamic activity against tumors after visible light treatment. This review summarizes the published data regarding these compounds: from the spectroscopic, photophysical and photochemical characteristics to the in vivo and in vitro photodynamic inactivation of tumors and normal tissue effects. Some mechanistic studies using both the Sn-etiopurpurin and/or the Cu-benzochlorin derivatives are also reviewed.

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