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Purity determinations in the bulk drug of the novel indoloquinone antitumor agent EO9

โœ Scribed by Jantine D. Jonkman-de Vries; J. Jantina Kettenes-van den Bosch; Roland E. C. Henrar; Auke Bult; Jos H. Beijnen


Book ID
104666280
Publisher
Springer US
Year
1996
Tongue
English
Weight
746 KB
Volume
14
Category
Article
ISSN
0167-6997

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A chirally catalysed ene reaction in a n
โœ Michael R Pitts; Johann Mulzer ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 182 KB

A short highly efficient synthesis of the C3 C16 fragment 2 of laulimalide 1 is described. Fragment 2 was a key intermediate in a previous approach and thus constitutes a formal total synthesis with improved efficiency. The key steps are an Evans' alkylation, a Brown allylation and a chirally cataly