The aim of the present study was to investigate the mechanisms regulating endothelin-1 (ET-1) secretion in rat thyroid FRTL-5 cells. ET-1 was found to be secreted after stimulation with adenosine and ATP. The release of ET-1 was sensitive to pertussis toxin, indicating a role of G-proteins in the st
Purinergic agonist ATP is a comitogen in thyroid FRTL-5 cells
✍ Scribed by Kid Törnquist; Elina Ekokoski; Benoit Dugué
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 627 KB
- Volume
- 166
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Receptor-mediated calcium entry was investigated in Fura 2 loaded FRTL-5 cells. The purinergic agonist ATP activated the release of sequestered calcium and the entry of extracellular calcium. Downregulation of protein kinase C (PKC) substantially enhanced the ATP-evoked calcium entry. Pretreatment o
We investigated the mechanism of phospholipase A 2 (PLA 2 ) activation in response to the P2 receptor agonist ATP in rat thyroid FRTL-5 cells. The PLA 2 activity was determined by measuring the release of [ 3 H]-arachidonic acid (AA) from prelabeled cells. ATP evoked a dose-and time-dependent AA rel