✦ LIBER ✦

Purine nucleoside phosphorylase polymorphism in sheep erythrocytes

✍ Scribed by P. G. Board; J. E. Smith

Publisher: Springer
Year: 1977
Tongue: English
Weight: 227 KB
Volume: 15
Category: Article
ISSN: 0006-2928
DOI: 10.1007/bf00520189

No coin nor oath required. For personal study only.

✦ Synopsis

A polymorphism of purine nucleoside phosphorylase is described in sheep erythrocytes. Two isozymes were distinguished electrophoretically, one with high activity (NP-1) and one with low activity (NP-2). Breeding data suggest that the two isozymes are the product of two codominant alleles, NP1 and NP2. The Km's for inosine did not differ between NP-1 and NP-2; however, NP-2 had a lower pH optimum and was relatively unstable when incubated at 48 C.

📜 SIMILAR VOLUMES

Altered purine and pyrimidine metabolism

Altered purine and pyrimidine metabolism in erythrocytes with purine nucleoside phosphorylase deficiency

✍ Irving H. Fox; Jan Kaminska; N. Lawrence Edwards; Erwin Gelfand; Kenneth C. Rich 📂 Article 📅 1980 🏛 Springer 🌐 English ⚖ 771 KB

Purine and pyrimidine metabolism was compared in erythrocytes from three patients from two families with purine nucleoside phosphorylase deficiency and T-cell immunodeficiency, one heterozygote subject for this enzyme deficiency, one patient with a complete deficiency of hypoxanthine-guanine phospho

Purine nucleoside phosphorylase polymorp

Purine nucleoside phosphorylase polymorphism in the genusLittorina(Prosobranchia: Mollusca)

✍ Andrew J. Knight; Robert D. Ward 📂 Article 📅 1986 🏛 Springer 🌐 English ⚖ 466 KB

Examination of eight Atlantic species of the genus Littorina by starch gel electrophoresis of purine nucleoside phosphorylase revealed extensive polymorphism within the L. saxatilis complex. In this group, four alleles have been identified. Heterozygotes are four banded, and thus, as in vertebrates,

Mutations in purine nucleoside phosphory

Mutations in purine nucleoside phosphorylase deficiency

✍ M. Louise Markert; Bruce D. Finkel; Tanya M. McLaughlin; TJ Watson; Harold R. Co 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB

Purine nucleoside phosphorylase deficiency is an inherited disease of purine metabolism characterized clinically as combined immunodeficiency. The molecular defects have been published for 4 different alleles in 3 patients. We report four new mutations including two amino acid substitutions, A 174P

Characterization of purine nucleoside ph

Characterization of purine nucleoside phosphorylase in leukemia

✍ Dr. Takayuki Morisaki; Naomi Horiuchi; Hisaichi Fujii; Shiro Miwa 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 404 KB

The G51S purine nucleoside phosphorylase

The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimer's disease patients

✍ Emanuela Tumini; Elisa Porcellini; Martina Chiappelli; Chiara M. Conti; Alina Be 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB

## Abstract Alzheimer's disease (AD) is a polygenic and multifactorial complex disease, whose etiopathology is still unclear, however several genetic factors have shown to increase the risk of developing the disease. Purine nucleotides and nucleosides play an important role in the brain. Besides th

Genetic control of nucleoside transport

Genetic control of nucleoside transport in sheep erythrocytes

✍ S. M. Jarvis; J. D. Young 📂 Article 📅 1978 🏛 Springer 🌐 English ⚖ 404 KB

Nucleoside transport in sheep erythrocytes is under the genetic control of two allelomorphic genes (NuI and Nui), where NuI codes for the functional absence of a high-affinity nucleoside transport system and is dominant to the gene (Nui) coding for the presence of the transport system. Kinetic and i