✦ LIBER ✦

Purified colony stimulating factors (G-CSF and GM-CSF) induce differentiation in human HL60 leukemic cells with suppression of clonogenicity

✍ Scribed by C. Glenn Begley; Donald Metcalf; Nicos A. Nicola

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 854 KB
Volume: 39
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910390118

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✦ Synopsis

Purified recombinant human granulocyte-macrophage col- HL60 (Metcalf, 1983) and similar results were observed using ony-stimulating factor (rHGM-CSF) and purified native mu-comparable material from other media containing human CSFs rine granulocyte-CSF (G-CSF) both induced differentiation in (plaker et al., 1985;Ruscetti al.. 1981: Elias et 01.. 1980).

HL60 cells as evidenced by expression of granulocyte and macrophage membrane antigens, although this was not ac-l~~ whom reprint requests should be sent.

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I9 102 A voltage-activated inward-rectifying K + conductance (IK,) appears in human promyelocytic leukemia (HL-60) cells during phorbol ester-induced differentiation into macrophages. This conductance was detected in the cells 24 hours after exposure to phorbol-12-myristate-13-acetate (PMA), as the