Purification of tritiated phenacetin and N-acetyl-p-aminophenol

✍ Scribed by H. P. Singh; M. H. Gault

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: French
• Weight: 141 KB
• Volume: 8
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2590080407

✦ Synopsis

Abstract

Phenacetin and N‐acetyl‐p‐aminophenol (NAPA) tritiated by catalytic exchange (1), were quite impure as purchasedNew England Nuclear Corp., Boston, Mass. 02118.

No previous reports on purification of these radioactive compounds could be found, although there are reports of separation of phenacetin or NAPA by chromatography (2, 3). Purificaion was carried out in two steps : gel filtration with Sephadex G‐10, followed by thin layer chromatography on silica gel.