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Purification of thrombin by affinity chromatography on immobilized heparin

✍ Scribed by Birgitta Nordenman; Ingemar Björk

Book ID
119033555
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
690 KB
Volume
11
Category
Article
ISSN
0049-3848

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Mechanism of thrombin inactivation by im
Mechanism of thrombin inactivation by immobilized heparin
✍ Byun, Youngro ;Jacobs, Harvey A. ;Wan Kim, Sung 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 496 KB

The ability of heparin to interact with plasma proteins, in particular antithrombin I11 (ATIII) and thrombin, is its primary mechanism as an anticoagulant drug. Research efforts have focused on the biological activity of heparin under three conditions: in solution as a free molecule, chemically coup