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Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases

โœ Scribed by Barbara Czarnocka; Jean Ruf; Mireille Ferrand; Pierre Carayon; Serge Lissitzky


Book ID
115916837
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
484 KB
Volume
190
Category
Article
ISSN
0014-5793

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Thyroid peroxidase (TPO) is the key enzyme in the synthesis of thyroid hormones. Defects in the TPO gene are reported to be the cause of congenital hypothyroidism due to a Total Iodide Organification Defect (TIOD). This type of defect, where iodide taken up by the thyroid gland cannot be oxidized an