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Purification of the Death Substrate Poly(ADP-ribose) Polymerase

✍ Scribed by Damien D'amours; Patrick J. Duriez; Kim Orth; Rashmi G. Shah; Vishva M. Dixit; William C. Earnshaw; Emad S. Alnemri; Guy G. Poirier

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
103 KB
Volume
249
Category
Article
ISSN
0003-2697

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✦ Synopsis

lose affinity chromatography. This part of the purifiand Guy G. Poirier* ,2 cation was performed according to Yoshihara et al. (7) *Poly(ADP-ribose) Metabolism Group, Health and as modified in Shah et al. (8). Briefly, the calf thymus

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## Abstract Poly(ADP‐ribose) polymerase‐1 (PARP‐1) is a mammalian enzyme that attaches long branching chains of ADP‐ribose to specific nuclear proteins, including itself. Because its activity __in vitro__ is dependent upon interaction with broken DNA, it has been postulated that PARP‐1 plays an imp