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Purification of human and monkey endonucleases acting on ultraviolet-irradiated DNA

โœ Scribed by Takanori Tomura; Julien L. Van Lancker


Book ID
115704664
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
304 KB
Volume
201
Category
Article
ISSN
0003-9861

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A Human Endonuclease Incises Ultraviolet
โœ Patricia E. Gallagher; Randi B. Weiss; Thomas P. Brent; Nahum J. Duker ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 359 KB

Both ultraviolet irradiation and oxidation of DNA produce a variety of pyrimidine base damages. A human endonuclease recognizes such altered bases on these DNA substrates. This human endonuclease incises ultraviolet-irradiated DNA exclusively at sites of photochemically modified cytosines. The preci