Purification of D&C Red. No. 33 by preparative high-performance liquid chromatography

✍ Scribed by John E. Bailey Jr.

• Book ID: 104146682
• Publisher: Elsevier Science
• Year: 1984
• Tongue: English
• Weight: 460 KB
• Volume: 314
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)97750-7

✦ Synopsis

Preparative reversed-phase high-performance liquid chromatography (HPLC) was used to purify a composite sample of D&C Red No. 33. A number of contaminating impurities were isolated from the dye and the purified material was essentially free of residual aromatic amines. A comparison was made between purification by preparative HPLC and recrystallization.