Purification of an α-2,8-Sialyltransferase, a Potential Initiating Enzyme for the Biosynthesis of Polysialic Acid in Human Neuroblastoma Cells

Overexpression of the α2,6 (N) sialyltra

Overexpression of the α2,6 (N) sialyltransferase enzyme in human and rat neural cell lines is associated with increased expression of the polysialic acid epitope

✍ Niki Georgopoulou; Kieran C. Breen 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 334 KB 👁 1 views

The function of the neural cell adhesion molecule, NCAM, is modulated by the expression of the Nlinked polysialic acid (PSA) oligosaccharide chain, with PSA serving to decrease the adhesive potential of the protein backbone. In this study, we have generated clonal cells of the rat B104 and human SH-