Purification and properties of the three o-diphenol-O-methyltransferases of tobacco leaves
β Scribed by Jean Collendavelloo; Michel Legrand; Pierrette Geoffroy; Joelle Barthelemy; Bernard Fritig
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 712 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0031-9422
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The three tobacco (Nicotiana tabacum L.) S-adenosyl-L-methionine: o-diphenol-O-methyltransferases (OMTs; EC 2.1.1.6) were purified to homogeneity by affinity chromatography on adenosine-agarose. Amounts and catalytic actities of the enzymes were measured in tobacco leaves during the hypersensitive r
The ionization and lipophilicity properties of the second-generation catechol-O-methyltransferase (COMT) inhibitors entacapone (1), nitecapone (2), and tolcapone (3) which share the same nitrocatechol structure but have remarkably different pharmacokinetic profiles are investigated to identify relat
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