✦ LIBER ✦

Purification and partial characterization of a putative mediator of insulin action on cyclic AMP-dependent protein kinase

✍ Scribed by M. P. Thompson; J. Larner; Daniel L. Kilpatrick

Publisher: Springer
Year: 1984
Tongue: English
Weight: 607 KB
Volume: 62
Category: Article
ISSN: 0300-8177
DOI: 10.1007/bf00230079

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✦ Synopsis

An insulin mediator which inhibits cAMP-dependent protein kinase has been purified approximately 1000-2000-fold from skeletal muscle. Following heat treatment, charcoal adsorption and Sephadex G-25 sieving, Sephadex G-15 sieving and HPLC over an anion exchange column were performed. The mediator has characteristics of a relatively low molecular weight peptide or derivatized peptide which acts on cAMP-dependent protein kinase but not on mitochondrial pyruvate dehydrogenase.

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