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Purification and characterization of cyclic AMP-specific phosphodiesterase (PDE) from human polymorphonuclear leukocytes (PMNs)

✍ Scribed by Donald C. Bode; Wayne Cumiskey; Edward D. Pagani; Paul J. Silver


Book ID
115985136
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
106 KB
Volume
24
Category
Article
ISSN
0022-2828

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DEAE-Sephadex chromatography reveals the presence in extracts of human bronchial tissue of at least three separate cyclic nucleotide phosphodiesterases: a cyclic GMP-specific high affinity enzyme, a non-specific low affinity enzyme, and a high affinity cyclic AMP-specific enzyme. The activity of eac