Purealidin D, a new pyridine alkaloid from the okinawan marine sponge psammaplysilla purea

✍ Scribed by Masashi Tsuda; Hideyuki Shigemori; Masami Ishibashi; Jun'ichi Kobayashi

• Publisher: Elsevier Science
• Year: 1992
• Tongue: French
• Weight: 178 KB
• Volume: 33
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)92253-6

✦ Synopsis

Purealidin D. a new alkaloid possessing a pyridinium and a bromotyrosine moiety was isolated from the Okinawan marine sponge Psammaplysilla purea and the structure elucidated on the basis of spectroscopic data. Among a variety of nitrogenous natural products from marine sponges, a number of brominated tyrosine-derived alkaloids have been isolated from species of the family Verongidae.1 We have also isolated several bioactive bromotyrosine metabolites from the Okinawan marine sponge Psammuplysillu pure& During our studies on bioactive substances from Okinawan marine organisms,4 extracts of P. purea were further investigated to isolate purealidin D (l), a new Na +, K+-ATPase inhibitory alkaloid containing a pyridinium and a bromotyrosine unit. This communication describes the isolation and structure elucidation of