𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pure dysgerminoma of the ovary in childhood: Treatment results and sequelae

✍ Scribed by Teinturier, C. ;Gelez, J. ;Flamant, F. ;Habrand, J. L. ;Lemerle, J.

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
567 KB
Volume
23
Category
Article
ISSN
0098-1532

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Thirty‐five children with pure dysgerminoma of the ovary were all treated at the Institut Gustave Roussy (IGR) from 1956–1985. The median follow‐up is 8.5 years. The crude 5‐year survival rate is 94.1% (±4.1). The disease‐free 5‐year survival rate is 81.8% (±6.7). Fourteen patients who had stage I disease were treated by unilateral salpingooophorectomy and prophylactic radiotherapy (20 Gy) to ipsilateral iliac, lumbar‐aortic, and subclavicular lymph nodes. All are alive without sequelae. Eighteen patients with stage II and III disease were treated by surgery and radiotherapy (30–40 Gy) to the tumor volume. All are alive but radio‐induced sequelae are severe. Five relapses of stage I, II, and III tumors occurred and were cured by a second line treatment. Two of the three patients with stage IV disease died.

Four patients received a cisplatinum‐containing regimen for disseminated disease or because of a relapse before radiotherapy. Three achieved a complete response of measurable tumor. Given the high efficacy of this kind of chemotherapy and the severe sequelae induced by abdomino‐pelvic irradiation, we propose initial chemotherapy for widespread disease andd radiotherapy in the event of residual tumor. © 1994 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

The treatment for dysgerminoma of the ov
The treatment for dysgerminoma of the ovary
✍ Garry Krepart; Julian P. Smith; Felix Rutledge; Luis Delclos 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 390 KB 👁 2 views

Tumor Institute between 1947 and 1974. Twenty-six of these patients had their initial surgery at the M. D. Anderson Hospital or were referred to the M. D. Anderson Hospital shortly after surgery at another hospital. The remaining 10 were referred after developing a recurrence of their tumor. Five of

Medulloblastoma in childhood: Long-term
Medulloblastoma in childhood: Long-term results of treatment
✍ V. A. Broadbent; N. D. Barnes; T. K. Wheeler 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 443 KB 👁 3 views

Thirty-one children under the age of 15 years with verified medulloblastoma were treated at Addenbrookes Hospital from 1940 to 1976. In addition to surgical treatment, all received high dose irradiation to the whole neuraxis. Nine were still alive in 1979, of whom eight were examined. All these pati

Results of radiation therapy in the trea
Results of radiation therapy in the treatment of epithelial carcinoma of the ovary
✍ Judith S. Haas; Carl M. Mansfield; Gerald V. Hartman; Eashwer K. Reddy; Byron J. 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 443 KB 👁 2 views

Between 1967 and 1976, 82 patients who had epithelial carcinoma of the ovary and were treated with surgery and postoperative radiation therapy, respectively, were studied. Of these patients, 35% had Stage I disease, 16% Stage 11, 45% Stage 111, and 4% Stage IV. Serous cystadenocarcinoma was the hist