## Communicated by Mireille Claustres Hereditary spastic paraplegias (HSP) constitute a heterogeneous group of neurodegenerative disorders characterized by slowly progressive spasticity of the lower extremities. Only a few different mutations in the SPG10 gene, KIF5A, have been described in pure d
✦ LIBER ✦
‘Pure’ and ‘Complicated’ Forms of Hereditary Spastic Paraplegia Presenting in Childhood
✍ Scribed by R. E. Appleton; K. Farrell; H. G. Dunn
- Book ID
- 115265782
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 644 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0012-1622
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Hereditary spastic paraplegia (HSP) describes a heterogeneous group of inherited neurodegenerative disorders in which the cardinal pathological feature is upper motor neurone degeneration leading to progressive spasticity and weakness of the lower limbs. Using samples from a large Omani family we re