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Pure adult-onset Spastic Paraplegia caused by a novel mutation in theKIAA0196(SPG8) gene

✍ Scribed by Susanne T. de Bot, Sascha Vermeer, Wendy Buijsman, Angelien Heister…


Book ID
120898535
Publisher
Springer
Year
2013
Tongue
English
Weight
405 KB
Volume
260
Category
Article
ISSN
0340-5354

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Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterised by progressive spasticity and hyperreflexia of the lower limbs. Autosomal dominant hereditary spastic paraplegia linked to the SPG3A locus on chromosome 14q11-2