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Pulse radiolytic investigations of superoxide catalyzed disproportionation. Mechanism for bovine superoxide dismutase

✍ Scribed by Klug-Roth, Dina.; Fridovich, Irwin.; Rabani, Joesph.


Book ID
111931541
Publisher
American Chemical Society
Year
1973
Tongue
English
Weight
628 KB
Volume
95
Category
Article
ISSN
0002-7863

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Key charged residues in Cu,Zn superoxide dismutase (Cu,Zn SOD) promote electrostatic steering of the superoxide substrate to the active site Cu ion, resulting in dismutation of superoxide to oxygen and hydrogen peroxide, Lys-136, along with the adjacent residues Glu-132 and Glu-133, forms a proposed