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Pulmonary toxicity associated with fludarabine monophosphate

✍ Scribed by Paul G. Hurst; Michael P. Habib; Harinder Garewal; Marlene Bluestein; Maria Paquin; Bernard R. Greenberg

Publisher: Springer US
Year: 1987
Tongue: English
Weight: 789 KB
Volume: 5
Category: Article
ISSN: 0167-6997
DOI: 10.1007/bf00203548

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✦ Synopsis

Fludarabine monophosphate (FAMP), the 2-fluoro, 5'phosphate derivative of 9-/3-D-arabinofuranosyl adenine (ara-A), is a purine nucleoside antimetabolite presently undergoing clinical testing for the treatment of a variety of malignancies including lymphoproliferative disorders and acute leukemia. We report a case of diffuse interstitial pneumonitis during treatment of chronic lymphocytic leukemia with FAMP. This resolved quickly with high dose steroids, recurred with steroid withdrawal, and abated with further steroid therapy. To our knowledge, this is the first reported case of fludarabine monophosphate associated pulmonary toxicity.

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