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Pulmonary function responses in cats following long-term exposure to diesel exhaust

✍ Scribed by William J. Moorman; John C. Clark; William E. Pepelko; Joan Mattox

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 448 KB
Volume: 5
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550050508

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✦ Synopsis

Long-term inhalation studies were carried out to evaluate the toxic pulmonary effects of diesel engine emissions. Cats were exposed for over 2 years to whole, diluted diesel exhaust at levels expected to produce frank toxic effects. During the first 61 weeks of exposure, the cats received exhaust having a particulate level of 6 mg m-3. This was followed by a doubling of the exposure level from weeks 62 to 124 resulting in particulate levels of 12 mg m-3. No definitive pattern of pulmonary function response was observed following 61 weeks; however, a classic pattern of restrictive lung disease was found at 124 weeks. The significantly reduced lung volumes and diffusing capacity were indicative of a pulmonary interstitial response which was later verified by histopathology.

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