Pulmonary crystal-storing histiocytosis diagnosed by computed tomography-guided fine-needle aspiration
✍ Scribed by William U. Todd; Joseph J. Drabick; Michael G. Benninghoff; Elizabeth E. Frauenhoffer; Dani S. Zander
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 229 KB
- Volume
- 38
- Category
- Article
- ISSN
- 8755-1039
- DOI
- 10.1002/dc.21193
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Crystal‐storing histiocytosis (CSH) is a rare process most often occurring in conjunction with an underlying hematopoietic neoplasm, usually multiple myeloma or low‐grade B‐cell lymphoma. We report the first case of pulmonary CSH diagnosed by fine‐needle aspiration biopsy. A patient with a history of urothelial carcinoma developed a lung nodule, which was evaluated by fine‐needle aspiration biopsy. Cytologic examination revealed macrophages with abundant cytoplasmic crystals diagnostic of CSH. Based on this cytologic interpretation, additional clinical laboratory evaluation was pursued and revealed a previously unknown monoclonal serum protein. CSH must be differentiated from other non‐neoplastic and neoplastic lesions and when diagnosed, should trigger a search for an underlying lymphoproliferative disorder. Diagn. Cytopathol. 2010. © 2009 Wiley‐Liss, Inc.