✦ LIBER ✦

Pulmonary adenocarcinoma: classification and molecular biology

✍ Scribed by Carey, Francis A.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 28 KB
Volume: 184
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199803)184:3<229::aid-path18>3.0.co;2-0

No coin nor oath required. For personal study only.

✦ Synopsis

Pulmonary adenocarcinoma is increasing in incidence. Current classification systems based purely on morphological features are of little clinical relevance. Recent descriptions of genetic abnormalities, particularly in K-ras, p53, and c-erb-B2, may form the basis of a new taxonomy having direct prognostic relevance. Study of these molecular lesions has also helped to define a new pathway of tumourigenesis in the lung parenchyma, through alveolar atypical hyperplasia (AAH) to clinical adenocarcinoma. 1998 John Wiley & Sons, Ltd.

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