Publishing trends in hepatology

✍ Scribed by P J Scheuer

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 123 KB
• Volume: 23
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.510230558

✦ Synopsis

the concentration of electrolytes and organic osmo-tol 11 rather than a stimulation of its release, which is a faster process. Time-dependent changes in organic lytes. 4 Organic osmolytes correspond to the previously termed ''idiogenic osmoles.'' They are ubiquitous in na-osmolytes may be involved in the protection from brain edema in chronic liver failure. Attempts to change the ture, and long-term changes in their concentration are better tolerated by cells than those of electrolytes. In concentration of organic osmolytes may open a new therapeutic approach to brain edema in ALF. the brain-a tissue in which regulation of cell volume is essential-myo-inositol and glutamine are quantitatively two important organic osmolytes. Whereas JUAN CORDOBA, M.D. changes in the concentration of electrolytes occurs rap-Department of Medicine idly, modification of organic osmolytes is a slow process.

Northwestern University The previous report of H 1 -MRS in a patient with Reye's Chicago, IL syndrome 2 showed a decrease in myo-inositol levels REFERENCES from baseline to 1 week later. In experiments in our laboratory, we have observed that changes in cortical 1. McConnell JR, Antonson DL, Ong CS, Chu WK, Fox IJ, Heffraon organic osmolytes measured by HPLC in rats with por-TG, Langnas AN, et al. Proton spectroscopy of brain glutamine in acute liver failure. HEPATOLOGY 1995;22:69-74. tacaval anastomoses are time dependent. 5 Although a 2. Ernst T, Ross BD, Flores R. Cerebral MRS in infant with sussimilar increase in glutamine concentration (Ç200%) pected Reye's syndrome (letter). Lancet 1992;340:486. occurred 1 day and 3 weeks after surgery, the decrease 3. Ross BD, Jacobson S, Villamil F, Korula J, Kreis R, Ernst T, in myo-inositol levels was more pronounced after 3 Shonk T, et al. Subclinical hepatic encephalopathy: proton MR weeks (15% vs. 40%).