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Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain

✍ Scribed by Tremblay, J. J.


Book ID
111746027
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
473 KB
Volume
18
Category
Article
ISSN
0261-4189

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Plasminogen activator inhibitor-1 regula
✍ Gary Deng; Scott A. Curriden; Geng Hu; Ralf-Peter Czekay; David J. Loskutoff πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 247 KB

## Abstract Plasminogen activator inhibitor‐1 (PAI‐1) binds to the somatomedin B (SMB) domain of vitronectin. It inhibits the adhesion of U937 cells to vitronectin by competing with the urokinase receptor (uPAR; CD87) on these cells for binding to the same domain. Although the inhibitor also blocks