PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic β-catenin and affects membrane distribution of β-catenin/E-cadherin complexes in cancer cells

Regulation of cell morphology and adhesi

Regulation of cell morphology and adhesion by the tuberous sclerosis complex (TSC1/2) gene products in human kidney epithelial cells through increased E-cadherin/β-catenin activity

✍ Shaowei Li; Richard Braverman; Hongzhen Li; William C. Vass; Douglas R. Lowy; Je 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 542 KB

## Abstract We investigated the effects of overexpression of the tuberous sclerosis‐1 and ‐2 (__TSC1/2__) gene products (hamartin and tuberin, respectively) in the human kidney epithelial cell line 293 with an inducible expression system. As we had observed previously in fibroblasts, 293 cells over