PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor of vascular endothelial growth factor (VEGF), has modest activity in myelofibrosis with myeloid metaplasia
✍ Scribed by Francis J. Giles; Alan F. List; Michael Carroll; Jorge E. Cortes; Joyce Valickas; Bee-Lian Chen; Eric Masson; Christian Jacques; Dirk Laurent; Maher Albitar; Eric J. Feldman; Gail J. Roboz
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 151 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0145-2126
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## Abstract ## BACKGROUND Increased bone marrow angiogenesis and vascular endothelial growth factor (VEGF) levels are of adverse prognostic significance in patients with myeloproliferative disorders (MPD), including agnogenic myeloid metaplasia (AMM), chronic myeloid leukemia in blastic phase (CML