Pterin Chemistry. Part 92.. Loading experiments with 6α,β-tetrahydro-L-[3′-2H1] biopterin
✍ Scribed by Carmen Adler; Hans-Christoph Curtius; Erich Wetzel; Max Viscontini; Tullio A. Giudici; Milan Blaskovics; Marie O. Rolland; Pierre Guibaud
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- German
- Weight
- 268 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
6α,β‐Tetrahydro‐L‐[3′‐^2^H~1~]biopterin ([3′‐^2^H~1~]‐1) was administered orally to two primapterinuric patients in order to investigate the biosynthetic pathway of 7‐substituted pterins in humans. L‐Primapterin (2) and L‐biopterin were isolated from urine after loading and measured by GC/MS. L‐Biopterin and L‐primapterin were labelled with ^2^H to an equal extent. From this result, one can conclude that L‐primapterin is formed from tetrahydro‐L‐biopterin, very probably via an intramolecular rearrangement.