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PTEN and leukemia stem cells

✍ Scribed by Fragoso, Rita (author);Barata, João T. (author)

Book ID
125449069
Publisher
Elsevier Ltd
Year
2014
Tongue
English
Weight
401 KB
Volume
56
Category
Article
ISSN
2212-4926

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## Abstract Leukemia stem cells (LSCs) might originate from malignant transformation of normal hematopoietic stem cells (HSCs), or alternatively, of progenitors in which the acquired mutations have re‐installed a dysregulated self‐renewal program. LSCs are on top of a hierarchy and generate leukemi