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Psychostimulant augmentation of second generation antidepressants: A case series

✍ Scribed by Prakash S. Masand; Vishal S. Anand; John F. Tanquary

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 48 KB
Volume: 7
Category: Article
ISSN: 1091-4269
DOI: 10.1002/(sici)1520-6394(1998)7:2<89::aid-da8>3.0.co;2-0

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✦ Synopsis

Objective:

The authors attempted to treat major depressive disorder (mdd) suboptimally responsive to one of the newer (second-generation) antidepressants by augmentation with a psychostimulant medication.

Method:

Seven cases of mdd showing a partial response to an adequate trial of a second generation antidepressant were augmented with a psychostimulant.

Results:

A marked improvement in clinical symptoms of depression was noted in all cases, with particular improvement in apathy and feelings of fatigue.

Conclusion:

Psychostimulant augmentation of the newer generation antidepressants is a promising new strategy. further controlled investigation is warranted to explore various aspect of this method.

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