Psychophysiological approach in Parkinson's disease:L-dopa effects on preprogramming and control activity
β Scribed by F. Fattapposta; F. Pierelli; F. My; M. Mostarda; S. Del Monte; L. Parisi; M. Serrao; N. Locuratolo; G. Amabile
- Publisher
- Springer Milan
- Year
- 2002
- Tongue
- English
- Weight
- 38 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1590-1874
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Cisapride (CIS) is a prokinetic agent that increases gastrointestinal motility in normal individuals and improves constipation in Parkinson's disease (PD). We studied the effects of CIS on the clinical response and the peripheral pharmacokinetics of orally administered L-dopa given to patients with
## Abstract It has been suggested that patients with Parkinson disease partially compensate for neuron loss by developing denervation supersensitivity, and, if so, that prolonged levodopa (Lβdopa) therapy might lead to desensitization. As a preliminary test of this hypothesis, and in order to study