A latent structure analysis of pharmaceutical formulations was performed using Kohonen's self-organizing map (SOM) and a Bayesian network. A hydrophilic matrix tablet containing diltiazem hydrochloride (DTZ), a highly water-soluble model drug, was used as a model formulation. Nonlinear relationship
โฆ LIBER โฆ
Psychographic clustering of blood donors in Egypt using Kohonen's self-organizing maps
โ Scribed by Mohamed M. Mostafa
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 309 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1465-4520
- DOI
- 10.1002/nvsm.376
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The response surface method incorporating multivariate spline interpolation (RSM-S) is a powerful technique for the formulation optimization of pharmaceuticals. However, no satisfactory method has been developed to evaluate the reliability of the optimal solution. We integrated bootstrap (BS) resamp