Psychiatric disorders, myoclonus dystonia, and the epsilon-sarcoglycan gene: A systematic review

✍ Scribed by Kathryn J. Peall; Adrian J. Waite; Derek J. Blake; Mike J. Owen; Huw R. Morris

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 678 KB
• Volume: 26
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.23791

✦ Synopsis

Abstract

Background:

Mutations in the maternally imprinted epsilon‐sarcoglycan gene occur in 30%–50% of myoclonus‐dystonia cases. Psychiatric symptoms, particularly obsessive‐compulsive disorder, have been described in some patients.

Methods:

We systematically reviewed 22 reports of psychiatric symptoms in myoclonus‐dystonia, dividing individuals according to clinical and mutation status.

Results:

Clinically manifesting mutation carriers demonstrated an excess of psychiatric disorders compared with nonmutation carriers (P < .001). No differences were seen between non‐motor‐manifesting carriers and nonmutation carriers with the exception of alcohol excess/dependence, higher in non‐motor‐manifesting carriers.

Conclusions:

The results confirm the association of epsilon‐sarcoglycan gene mutations with psychiatric disease and suggest a possible separation of the motor and psychiatric effects. © 2011 Movement Disorder Society