Psychiatric disorders in Ecstasy (MDMA) users: a literature review focusing on personal predisposition and drug history
✍ Scribed by K. Soar; J. J. D. Turner; A. C. Parrott
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 56 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0885-6222
- DOI
- 10.1002/hup.350
No coin nor oath required. For personal study only.
✦ Synopsis
3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) has been implicated in the onset of a number of psychological disorders and associated with a number of psychiatric symptoms that have persisted after cessation of the drug. This paper is a review of the published psychiatric case studies from the last 10 years involving MDMA. Only 24% of patients had a previous psychiatric history and 34% had a psychiatric illness amongst first degree relatives. The percentage of patients not having had a personal or family history of psychiatric illness and the temporal relationship between MDMA ingestion and the experience of recurring symptoms strongly suggest a causal relationship between the drug and neuropsychiatric manifestations. Further supporting evidence comes from several studies using non-clinical samples. Ecstasy users that don't present themselves in healthcare settings as having clinical symptoms have significantly higher scores on certain subscales of the SCL-90 compared with Ecstasy-naive controls, with higher pathology scores in heavier Ecstasy users. The full-blown psychiatric cases may represent the broad end of this problematic spectrum. Copyright 2001 John Wiley & Sons, Ltd.