Psychiatric disorders and mutations at the Wolfram syndrome locus
β Scribed by Michael Swift; Ronnie Gorman Swift
- Book ID
- 119407658
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 43 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0006-3223
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
WFS1 is a novel gene and encodes an 890 amino-acid glycoprotein (wolframin), predominantly localized in the endoplasmic reticulum. Mutations in WFS1 underlie autosomal recessive Wolfram syndrome and autosomal dominant low frequency sensorineural hearing impairment (LFSNHI) DFNA6/14. In addition, sev
Bipolar affective disorder (BPAD) is a complex disease with a significant genetic component. Heterozygous carriers of Wolfram syndrome (WFS) are at increased risk of psychiatric illness. A gene for WFS (WFS1) has recently been cloned and mapped to chromosome 4p, in the general region we previously r