Pseudoscleroderma associated with lung cancer: correlation of collagen type I and connective tissue growth factor gene expression

✍ Scribed by C. Querfeld; S. Sollberg; C. Huerkamp; B. Eckes; T. Krieg

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 428 KB
• Volume: 142
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.2000.03579.x

✦ Synopsis

Abstract

Pseudoscleroderma as a paraneoplastic syndrome is a rare disease. We report here a patient with lung cancer (undifferentiated squamous cell carcinoma), who developed acrosclerosis. Using in situ hybridization, marked expression of α1(I)-collagen and connective tissue growth factor (CTGF) mRNA was found in fibroblasts scattered throughout the dermis. However, transforming growth factor (TGF)-β1 expression was not detected. The pattern of CTGF gene expression and collagen synthesis was similar to that in systemic scleroderma. The absence of TGF-β1 mRNA could indicate that tumour-derived factors induce the expression of CTGF.