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Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells

✍ Scribed by Dandan Zhao; Feng Lin; Xingde Wu; Qinshi Zhao; Binjiahui Zhao; Ping Lin; Yanlong Zhang; Xiaoguang Yu

Book ID
116920585
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
971 KB
Volume
26
Category
Article
ISSN
0887-2333

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## Abstract Androgen‐independent prostate cancers express high levels of Bcl‐2, and this over‐expression of Bcl‐2 protects prostate cancer cells from undergoing apoptosis. Ursolic acid (UA) has demonstrated an anti‐proliferative effect in various tumor types. The aim of this study is to evaluate th