𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pseudodynamic Combinatorial Libraries: A Receptor-Assisted Approach for Drug Discovery

✍ Scribed by Andrew D. Corbett; Jeremy D. Cheeseman; Romas J. Kazlauskas; James L. Gleason


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
167 KB
Volume
116
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Pseudodynamic Combinatorial Libraries: A
✍ Andrew D. Corbett; Jeremy D. Cheeseman; Romas J. Kazlauskas; James L. Gleason 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 167 KB 👁 1 views

Scheme 2. Competitive inhibition constants of the library members for the CA-catalyzed hydrolysis of p-nitrophenyl acetate. The non-sulfonamide compounds showed no detectable inhibition at 1 mm.

Structure–Activity Relationships by NMR:
✍ Prof. Dr. Horst Kessler 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 422 KB

The search for new lead structures for drug development was always a combination of serendipity and rational design. The possibility of discovering new, biologically active structures was dramatically increased by screening pools of substances. In the rational approach medicinal chemists optimized t