PSA-detected prostate cancer: Contrasts with palpable disease

✍ Scribed by Gerald J. Matthews; John A. Fracchia

• Book ID: 102437362
• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 322 KB
• Volume: 59
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930590108

✦ Synopsis

The clinical and pathologic characteristics of 100 consecutive men with clinically localized prostate cancer and staged by radical prostatectomy were reviewed. Men with impalpable prostate-specific antigen (PSA) detected cancers (Tlc) were contrasted against men with palpable disease (TB). Lesions were clinically staged as T l c in 53 men and TB in 47 men. Mean serum PSA for men with T l c cancers was 1 I .8 & 0.7 ng/dL (normal: 0 > 4) and 14.1 * 1.7 ng/dL for men with TB disease. Histologic evaluation revealed a mean Gleason's sum of 6.4 2 0.2 (scale: 2 > 10) for Tlc lesions and 6.6 2 0.2 for men with TB cancers (P = NS). DNA content was diploid in 67% of T l c cancers and 62% of TB lesions (P = NS). An overall 43% clinical staging error was observed. Extraprostatic extension was demonstrated in 36% of T l c cancers and 51% TB lesions ( P = NS). PSA-detected cancers were indistinguishable from palpable lesions by all measures evaluated. Prostate cancers detected in asymptomatic men by an elevated PS A should be considered biologically significant lesions.