PS3-35 Caspase-1 processes high mobility group box 1 and is required for its release during infection and septic shock

Suppression of RANKL-dependent heme oxyg

Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis

✍ Eiko Sakai; Megumi Shimada-Sugawara; Kazuhisa Nishishita; Yutaka Fukuma; Mariko 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 825 KB

## Abstract The differentiation of osteoclasts is regulated by several essential cytokines, such as receptor activator of nuclear factor κB ligand (RANKL) and macrophage colony‐stimulating factor. Recently, high mobility group box 1 (HMGB1), a chromatin protein, also has been identified as one of t