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PS1-12 Alarmins activate immune responses by inducing dendritic cell chemotaxis and maturation

✍ Scribed by Joost J. Oppenheim; Poonam Tewary; Gonzalo de la Rosa; De Yang


Book ID
116399574
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
51 KB
Volume
52
Category
Article
ISSN
1043-4666

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The production of IL-12 by dendritic cells (DC) early in an immune response is considered critical for the polarization of CD4 + T lymphocyte response towards a Th1 pattern, a key process in the clearance of intracellular pathogens. Infection of bone marrow-derived DC with Mycobacterium bovis Bacill