Présence d'une Protéine D'origine Tissulaire, L'α2H-Globuline, Dans le Sérum de Sujets Atteints d'Affections Malignes

✍ Scribed by D. Buffe; C. Rimbaut; P. Burtin

• Publisher: John Wiley and Sons
• Year: 1968
• Tongue: French
• Weight: 464 KB
• Volume: 3
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910030618

✦ Synopsis

PATIENTS WITH NEOPLASTIC DISEASES

The presence of an u I globulin of probable hepatic origin has been demonstrated by immunodiffusion and radioimmunodiffusion techniques in sera of patients with neoplastic diseases.

-199 out of 395 (50%) of the sera of cancer patients were positive for u,H.

-71 out of 355 (20%) of pathological but non cancerous sera were positive -None of the 45 normal control sera showed the presence of the u , H protein.

The a,H protein is found more frequently in cancerous than in non cancerous sera. However, at present, a diagnostic test cannot be derived from its absence or presence. The discovery of a malignancy in a certain number of sera originally classified as non cancerous incites to pursue our investigations. The elevated percentage of positive pathological sera is suggestive of a reactivity factor. Diferent factors liable to interfere with the results are discussed. The presence of u L H could be a symptom of a metabolic hepatic reaction similar to that giving vise to the u,AP globulin in the rat.