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PrP Polymorphisms Associated with Natural Scrapie Discovered by Denaturing Gradient Gel Electrophoresis

✍ Scribed by J.L. Laplanche; J. Chatelain; D. Westaway; S. Thomas; M. Dussaucy; J. Brugere-Picoux; J.M. Launay


Book ID
115611382
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
583 KB
Volume
15
Category
Article
ISSN
0888-7543

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Gilbert's syndrome, due to reduced hepatic bilirubin glucuronidation is associated with the presence of two extra nucleotides (TA) in the promoter region of the UDP-glucuronosyltransferase 1 (UGT1A1) gene. A rapid method was developed to detect this genetic polymorphism, using double gradient denatu