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Proximity versus allostery: the role of regulated protein dimerization in biology

โœ Scribed by David J. Austin; Stuart L. Schreiber; Gerald R. Crabtree


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
760 KB
Volume
1
Category
Article
ISSN
1074-5521

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## Abstract Early biochemical analyses of metabolic pathways assumed that the free diffusion of substrates and enzymes in an evenly mixed cellular space provided the interactions that enabled reactions to proceed. Metabolic complexes have since been shown to assemble and disassemble in response to