Proximal tubular reabsorption of some organic acids in the rat kidney in vivo

✍ Scribed by Harald Sonnenberg; Hellmut Oelert; Karl Baumann

• Publisher: Springer
• Year: 1965
• Tongue: English
• Weight: 520 KB
• Volume: 286
• Category: Article
• ISSN: 0031-6768
• DOI: 10.1007/bf00363859

✦ Synopsis

Using a microperfusion technique proximal tubular reabsorption of sulfamerazine, phenobarbital, p-aminohippurie acid, uric acid, sulfaurea and N 4acetylsulfamcrazine was studied as a function of intratubtflar pH in the rat kidney in vivo. Transtubular permeabilities were related to in vitro lipoid solubility measurements and degrees of non-dissociation of the acids. It was found that 1. sulfamerazine and phenobarbital exhibit nonionic backdiffusion, the magnitude of which is dependent on lipoid solubility, 2. p-aminohippuric acid, uric acid and sulfaurea do not show this backdiffusion, a finding explained by lack of lipoid solubility, 3. N4-acetylsulfamerazine, despite relatively high lipoid solubility, is not reabsorbed in the proximal tubule.