Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T
✍ Scribed by Shalom Michaeli; Michael Garwood; Xiao-Hong Zhu; Lance DelaBarre; Peter Andersen; Gregor Adriany; Hellmut Merkle; Kamil Ugurbil; Wei Chen
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 111 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Carr‐Purcell and Hahn spin‐echo (SE) measurements were used to estimate the apparent transverse relaxation time constant (T) of water and metabolites in human brain at 4T and 7T. A significant reduction in the T values of proton resonances (water, N‐acetylaspartate, and creatine/phosphocreatine) was observed with increasing magnetic field strength and was attributed mainly to increased dynamic dephasing due to increased local susceptibility gradients. At high field, signal loss resulting from T decay can be substantially reduced using a Carr‐Purcell‐type SE sequence. Magn Reson Med 47:629–633, 2002. © 2002 Wiley‐Liss, Inc.