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Proton relaxation enhancement of albumin, immunoglobulin g, and fibrinogen labeled with gd-dtpa

✍ Scribed by Hannu Paajanen; Timo Reisto; Ilkka Hemmilä; Markku Komu; Pekka Niemi; Martti Kormano

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 351 KB
Volume: 13
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910130106

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Bovine serum albumin, immunoglobulin G, and fibrinogen were labeled with Gd‐DTPA using a bifunctional chelating agent DTPA anhydride. The protein‐(Gd‐DTPA) conjugates had 1.4‐ to 2.0‐fold greater longitudinal relaxivities at 0.02 and 0.44 T than the relaxivity of plain Gd‐DTPA. The increase of longitudinal relaxivity was not directly related to the size of carrier protein. Up to 50 Gd‐DTPA chelates per protein, longitudinal relaxivity of the conjugates was proportional to the concentration of Gd and independent of the Gd/protein ratio.

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